Science & Technology

The application of specifically configured magnetic fields as a means of positively affecting the partitioning, diffusion and transdermal passage of drug and other active molecules is the core expertise of OBJ Limited.

Having invented, developed and refined our patented technology to a high level of formulation and molecular specificity, OBJ is able to leverage our intellectual property to achieve new levels of product performance far beyond that of normal formulation chemistry.

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Modes of Action

Diamagnetic Repulsion

The property where matter with paired electrons is repulsed by a magnetic field. OBJ harnesses this force to control the rate, depth of penetration and delivery pathway of active ingredients during diffusion and partitioning.

Induced Charge Permeation

The property of a moving magnetic field to induce micro-fluidic flow conditions in the complex appendageal structures of the skin, in fabrics and on hard surfaces.

Energy Redirection

The property of surface charge accumulation involving the capture of motional energy of normal consumer behaviour during product use to alter surface flow characteristics and penetration in target barriers.

Technology Formats

Magnetic Micro-array Technology

Static Micro-arrays

Film-based micro-array technology ideal for patches, masks, dressings and other topical stationary applications.  The special magnetic micro-array elements are designed to optimise the effects of occlusion and to impart directional energy to target molecules.  Structurally, a low-cost thin film product that replaces the traditional plastic backing layer used in conventional patch designs.  The magnetic field elements that interact with each active ingredient and the barrier function of the target biology, are programmed in factory and can be die-cut to virtually any shape or size.

Field in Motion (FIM) Micro-arrays

A special magnetic micro-array film for integration into brushes, applicators and wipes, that captures the energy of motion of normal consumer behaviour and redirects that to achieve new levels of product performance and surface penetration.

Magnetic structures within the micro-array are developed to enhance delivery of active ingredients and to focus these at structures and pathways such as epidermal pores, follicles and dentine tubules.

Well suited to brushes, scrubs, wipes, applicators and various products where consumer movement and manipulation form part of normal usage patterns.

Powered Technology Platform

Dermaportation

Complex time-varying magnetic fields provide greater power, programmability, multiple formulation capability and configuration to individual skin types according to age and ethnicity.  It is a highly flexible product development platform that enables a wide range of commercial applications.

eSkin

eSkin multi-product delivery system, employing OBJ’s powered technology, is designed to provide a wide range of product-specific, time-varying magnetic fields in a format ideal for enhanced delivery of multiple formulations. The platform opens up opportunities to create personalised delivery profiles powered by e-commence and web-programmable applications.

Measured Dosage Devices

A range of measured dose delivery and packaging solutions that can dispense a precise amount of pre-metered formulation onto the skin. These devices overcome the various limitations associated with tubes, tubs and jars such as the improper dosing of formulation, contamination issues and messiness.

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Journals & Articles

While OBJ predominantly  works with partner-owned  and proprietary molecules and formulations, the results of which are confidential, OBJ does make available some documentation, data and results to assist partners and collaborators to understand the benefits of magnetic micro-array drug delivery and its uses. The following links provide a selection of data that is available. 

Published Journal Articles

Journal of Pharmacy and Pharmacology
Benson H. A. E., Krishnan G., Liew Y., Wallace V.P., Edwards J., Enhanced skin permeation and hydration by magnetic field array: preliminary in-vitro and in-vivo assessment. J Pharm Pharmacol (in press)

Journal of Pharmaceutical Science  2009
Krishnan, G.; Edwards, J.; Chen, Y.; Benson, H. A. E., Enhanced skin permeation of naltrexone by pulsed electromagnetic fields in human skin in vitro. J Pharm Sci 2009. DOI 10.1002/jps.22024

Biopolymers 2008
Namjoshi, S.; Chen, Y.; Edwards, J.; Benson, H. A. E., Enhanced transdermal delivery of a dipeptide by dermaportation. Biopolymers 2008, 90, (5), 655-62.

Journal of Chromatography
Namjoshi, S.; Caccetta, R.; Edwards, J.; Benson, H. A. E., Liquid chromatography assay for 5-aminolevulinic acid: application to in vitro assessment of skin penetration via Dermaportation. J Chromatogr B 2007, 852, (1-2), 49-55.

 

Peer Reviewed Publications

JPP-urea – Enhanced skin permeation and hydration by magnetic field array: preliminary in vitro and in vivo assessment

Dipeptide Publication – full version – Enhanced transdermal delivery of a Dipeptide by dermaportation

JPS_NTX09  – Enhanced skin permeation of naltrexone by pulsed electromagnetic fields in human skin in-vitro.

ALA-JChromo –  Liquid chromatography assay for 5-aminolevulinic acid: application to in-vitro assessment of skin penetration via Dermaportation.

 

International Presentations and Publications

  • Quirk, C.; Wallace, V. P.; Krishnan, G.; Benson, H. A. E., Magnetic enhanced transdermal drug delivery: in-vitro and in-vivo efficacy and mechanistic studies In Perspectives in Percutaneous Penetration Conference, La Grande Motte, France, 2010.
  • Namjoshi, S.; Chen, Y.; Edwards, J.; Benson, H. A. E., Electromagnetophoresis: potential for enhanced skin penetration of peptides. In Skin & Formulation 3rd Symposium and Skin Forum 10th Conference, Versailles, France, 2009.
  • Krishnan, G.; Wallace, V.; Edwards, J.; Benson, H. A. E., Electromagnetic field energy as a skin penetration enhancer: preliminary in-vitro and in-vivo assessment of skin permeation and hydration. In Controlled Release Society and Australasian Pharmaceutical Science Association Conference, Hobart, Tasmania, 2009.
  • Benson, H. A. E.; Edwards, J.; Krishnan, G.; Namjoshi, S., Electromagnetophoresis: potential for enhanced skin penetration of drugs and cosmetics In Skin & Formulation 3rd Symposium and Skin Forum 10th Conference, Versailles, France, 2009.
  • Benson, H. A. E.; Namjoshi, S.; Chen, Y.; Edwards, J., Enhanced transdermal delivery of a dipeptide by inductive energy. In Perspectives in Percutaneous Penetration Conference, La Grande Motte, France, 2008.
  • Namjoshi, S.; Benson, H.; Chen, Y.; Edwards, J. Enhanced transdermal delivery of a dipeptide by Dermaportation, 4th International Peptide Symposium, Cairns, Qld, 2007; Cairns, Qld, 2007.
  • Caccetta, R.; Eijkenboom, M.; Edwards, J.; Namjoshi, S.; Benson, H. A. E. Increased transdermal delivery of local anaesthetics by the novel penetration enhancement technology Dermaportation; in-vitro and in-vivo assessment, Pharmaceutical Science World Congress, Amsterdam, 2007; Amsterdam, 2007.
  • Benson, H.; Caccetta, R.; Eijkenboom, M.; Edwards, J. Dermaportation treated skin is more permeable to Voltaren Emulgel, World Congress on Inflammation, Copenhagen, 2007; Copenhagen, 2007.
  • Krishnan, G.; Caccetta, R.; Benson, H. A. E.; Edwards, J. Enhanced transdermal delivery of estradiol by Dermaportation, Australasian Pharmaceutical Science Association Annual Conference, Adelaide, 2006; Adelaide, 2006.
  • Benson, H. A. E.; Krishnan, G.; Caccetta, R.; Edwards, J. Dermaportation, a novel skin penetration enhancement technoloy: preliminary investigations with naltrexone, 10th Perspectives in Percutaneous Penetration Conference, La Grande Motte, France, 2006; La Grande Motte, France, 2006.
  • Benson, H. A. E.; Namjoshi, S.; Edwards, J., Dermal penetration enhancement by Dermaportation – Preliminary investigations of a novel technology. J Invest Dermatol 2005, 125, (6), A12.
  • Benson, H. A. E.; Namjoshi, S.; Edwards, J. Dermal delivery enhancement by Dermaportation – a novel penetration enhancement technology, 39th Annual Conference of the Australian Society of Cosmetic Chemists, Brisbane, 2005; Brisbane, 2005.
  • Benson, H. A. E.; Caccetta, R.; Namjoshi, S.; Edwards, J.; Eijkenboom, M. Rapid delivery of local anaesthetics by Dermaportation – a novel skin penetration enhencement technology, World Congress on Pain, Sydney, 2005; Sydney, 2005.
  • Namjoshi, S.; Caccetta, R.; Edwards, J.; Benson, H. A. E. Enhancement of skin penetration by Dermaportation, Australasian Pharmaceutical Science Association Annual Conference, Melbourne, 2004; Melbourne, 2004.

 

Booklets & Information Sheets

The following is an introduction to OBJ’s technology platform and links to papers on test data.